Dr Shaoqing Wei1, Fulin Wang2,3, Wanzhou Wang2,3, Chao Yang1,4, Feifei Zhang4, Luxia Zhang1,2,3,4
1RENAL DIVISION, DEPARTMENT OF MEDICINE, PEKING UNIVERSITY FIRST HOSPITAL, BEIJING, CHINA, 2NATIONAL INSTITUTE OF HEALTH DATA SCIENCE, PEKING UNIVERSITY, BEIJING, CHINA, 3INSTITUTE OF MEDICAL TECHNOLOGY, PEKING UNIVERSITY HEALTH SCIENCE CENTER, BEIJING, CHINA, 4CENTER FOR DIGITAL HEALTH AND ARTIFICIAL INTELLIGENCE, PEKING UNIVERSITY FIRST HOSPITAL, BEIJING, CHINA
Biography:
Shaoqing Wei is a PhD candidate in the Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China. Her research focuses on the prevention and management of chronic kidney disease, with particular interests in hypertension, cardiorenal risk factors, and population-based cohort studies. She is supervised by Professor Luxia Zhang and Associate Researcher Feifei Zhang. Her work aims to improve risk stratification and clinical outcomes for patients with chronic kidney disease through evidence from large-scale, multicentre studies.
Abstract:
Background
Hypertension is a leading cause of chronic kidney disease (CKD) progression and adverse cardiovascular outcomes. Ambulatory blood pressure monitoring (ABPM) enables comprehensive assessment of blood pressure patterns, including nocturnal systolic blood pressure (NSBP), yet evidence regarding the independent prognostic significance of NSBP in CKD patients remains limited and inconsistent.
Aim
To investigate the independent association between NSBP and cardiorenal outcomes in patients with CKD.
Methods
This multicentre cohort study included participants from the Chinese Cohort Study of Chronic Kidney Disease (C-STRIDE), enrolling patients from 39 clinical centres. Among 3,700 patients with CKD stages 1–4, 2,039 individuals with valid 24-hour ABPM records were analysed. NSBP was assessed using 24-hour ABPM. Outcomes included kidney failure and cardiovascular events. Cox proportional hazards models were used to estimate hazard ratios (HRs) per 10 mmHg increase in NSBP, with sequential adjustment for relevant covariates and additional adjustment for clinic systolic blood pressure to assess the independent prognostic value of NSBP.
Results
Over follow-up, higher NSBP was independently associated with increased risks of kidney failure and cardiovascular events. After full adjustment, each 10 mmHg increase in NSBP was associated with a higher risk of kidney failure (HR 1.12, 95% CI 1.05–1.20) and cardiovascular events (HR 1.11, 95% CI 1.01–1.22).
Conclusion
Elevated NSBP is an independent predictor of adverse kidney and cardiovascular outcomes in patients with CKD. These findings highlight the clinical importance of ABPM and nocturnal blood pressure control in risk stratification and management of CKD.