This unique case involves a 53-year-old woman of New Zealand European/Pakeha descent with end-stage renal disease on maintenance Hemodialysis who successfully managed Calciphylaxis through a combination of increased dialysis, diligent wound care, debridement, and sodium thiosulfate infusion. The rarity of Calciphylaxis in this population, coupled with the effective treatment approach, makes this case particularly noteworthy for healthcare professionals.